Upcoming webinars
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Speaker:
Marie-Laure CHARPIGNONPostdoctoral fellow in delivery science and clinical informatics at Kaiser Permanente Division of Research, in biostatistics and epidemiology at UC Berkeley Center for Targeted Machine Learning and Causal Inference, and in computational health informatics at Boston Children's Hospital
Visiting researcher at the Broad Institute of MIT and Harvard
Description :
Using electronic health record (EHR) data from a large US healthcare system, we emulated a target trial comparing the effectiveness of two highly prescribed antihypertensive drug classes at preventing or delaying the onset of dementia: ACE inhibitors (ACEi) versus Angiotensin Receptor Blockers (ARBs).
To test the assumption that ACEi may have an off-target pathogenic mechanism affecting the risk of dementia, we compared patients initiating an ACEi versus an ARB in the US Research Patient Data Registry of Mass General Brigham, comprising two academic hospitals and 33 clinics located in the Greater Boston area.
We performed intention-to-treat analyses among 25,507 patients aged 50 and over, applying Inverse Propensity score of Treatment Weighting to balance the two treatment arms and accounting for the competing risk of death. We found that patients initiating an ACEi had a 1.1 percentage point higher risk of dementia five years after treatment initiation and that such a detrimental effect was more pronounced among men.
Ongoing work includes evaluating differential effects by brain penetrance, discovering subgroups of responders, and assessing the mediating role of blood pressure (BP) control with ACEi versus ARB.
Future research will incorporate longitudinal markers (e.g., BP, HbA1c, LDL) in time-to-event models and consider stroke incidence or recurrence under ACEi versus ARB initiation as a mediator.
Keywords: target trial emulation; electronic health records; drug repurposing; dementia; hypertension
Event date:
Friday 21 November 2025, from 09:00 to 10:00 , (Paris, Europe)Organisé par :
Professeur Roch GIORGI - Equipe QuanTIM-SESSTIMSpeaker:
Yohann FOUCHERUniversité de Poitiers, CHU de Poitiers, CIC Inserm 1402 - Axe Scale-Epi (methodS in ClinicAL rEsearch and EPIdemiology)
Event date:
Friday 19 December 2025, from 11:00 to 12:00 , (Paris, Europe)Organisé par :
Professeur Roch GIORGI - Equipe QuanTIM-SESSTIMSpeaker:
Stéphanie ALLASONNIÈREUMR 1346, HeKA, Université Paris Cité, Inria, Inserm
Event date:
Friday 16 January 2026, from 11:00 to 12:00 , (Paris, Europe)Organisé par :
Professeur Roch GIORGI - Equipe QuanTIM-SESSTIMEvent date:
Friday 20 February 2026, from 11:00 to 12:00 , (Paris, Europe)Organisé par :
Professeur Roch GIORGI - Equipe QuanTIM-SESSTIMEvent date:
Friday 20 March 2026, from 11:00 to 12:00 , (Paris, Europe)Organisé par :
Professeur Roch GIORGI - Equipe QuanTIM-SESSTIMSpeaker:
Christian LAURENTUMR TransVIHMI (IRD, Inserm & Université de Montpellier)
Event date:
Friday 17 April 2026, from 11:00 to 12:00 , (Paris, Europe)Organisé par :
Professeur Roch GIORGI - Equipe QuanTIM-SESSTIMSpeaker:
Mathilde TOUVIERÉquipe de Recherche en Epidémiologie Nutritionnelle (CRESS-EREN), UMR U1153 Inserm / U1125 Inrae / Cnam / Université Sorbonne Paris Nord / Université Paris Cité
Event date:
Wednesday 13 May 2026, from 11:00 to 12:00 , (Paris, Europe)Organisé par :
Professeur Roch GIORGI - Equipe QuanTIM-SESSTIM
Description :
Stay tuned for all the information about the third edition of the PhD Student Award competition!
