Theme of the course and objectives

Net survival, the survival related to excess mortality hazard, is a measure of disease survival and can be interpreted as the survival that would be observed in a hypothetical situation where all the risks of dying from other causes than the disease of interest have been removed. The statistical methods for excess risk analysis have been developed to analyse data from population-based cancer registries, providing useful indicators to study socioeconomic inequalities in cancer survival, in the evaluation of health policies, and for public health decision making.

The complexity of the research questions and of the data, the necessity to have more adequate tolls, to improve the quality and the comparability of cancer survival data, and to promote methodological transfers in areas of emerging interest constitute some methodological challenges.

The course will focus on:

• the main statistical methods and the more recent advances in statistical methods for excess risk analysis;
• the transfer of methods for net survival estimations to some other specific applications (clinical research, occupational epidemiology).

The course will be taught by international researchers (France, United-Kingdom, and Slovenia) highly skilled in biostatistics, methodology, and epidemiology, from different research departments and implied in French (FRANCIM) and European (EUROCARE) networks of cancer registries.

The main objectives of the course are:

• to disseminate the concepts, methods and the more recent statistical tools to analyse net survival and excess mortality;
• to offer an informal and user-friendly setting of scientific exchanges in order to improve knowledge and practical skills to estimate, model, program, analyse and interpret results of excess risk analysis.

Programme

The scientific programme has been designed to meet the double objective of acquiring knowledge and skills in order to estimate, model, program using R software, analyse and interpret results of excess risk analysis.

Themes of the course:

• Goals, epistemological aspects
• Indicators-Interpretation
• Non-parametric estimators of net survival
• Parametric models for excess mortality
• Flexible parametric models for excess mortality
• Handling missing data
• Diagnostic tools
• Frailty models
• Multiple events analysis
• Handling expected rates tables (without, with missing information) and extensions to other fields: clinical research, epidemiology of occupational health

Scientific programme of the course

Faculty

An international faculty composed of international researchers (France, United-Kingdom, and Slovenia) highly skilled in biostatistics, methodology, and epidemiology, from different research departments and implied in French (FRANCIM) and European (EUROCARE) networks of cancer registries.

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	Aurélien Belot Inequalities in Cancer Outcomes Network, London School of Hygiene & Tropical Medicine, London, United-Kingdom			Guy Hédelin Institut National de Recherche et de Sécurité, Vandoeuvre-lès-Nancy, France
	Hadrien Charvat National Cancer Center, Tokyo, Japan			Valérie Jooste Registre Bourguignon des Cancers Digestifs FRANCIM, CHU de Dijon, INSERM 1231, Dijon, France
	Emmanuelle Dantony Hospices Civils de Lyon-UMR 5558, Université de Lyon, CNRS, France			Edmund Njeru Njagi Inequalities in Cancer Outcomes Network, London School of Hygiene & Tropical Medicine, London, United-Kingdom
	Mathieu Fauvernier Hospices Civils de Lyon-UMR 5558, Université de Lyon, CNRS, France			Maja Pohar-Perme Institute of Biostatistics and Medical Informatics, University of Ljubljana, Slovenia
	Roch Giorgi SESSTIM, UMR 1252, ISSPAM, Inserm/IRD/Aix-Marseille Université, France			Bernard Rachet Inequalities in Cancer Outcomes Network, London School of Hygiene & Tropical Medicine, London, United-Kingdom
	Juste Goungounga Registre Bourguignon des Cancers Digestifs, CHU de Dijon, EPICAD Team, INSERM 1231, Dijon, France			Laurent Remontet Hospices Civils de Lyon-UMR 5558, Université de Lyon, CNRS, France
	Michel Grzebyk Départment Épidemiologie en Entreprise, Institut National de Recherche et de Sécurité, Vandoeuvre-lès-Nancy, France			Laurent Roche Hospices Civils de Lyon-UMR 5558, Université de Lyon, CNRS, France
	Zoé Urhy Santé Publique France - Hospices Civils de Lyon-UMR 5558, Université de Lyon, CNRS, France			Pascale Grosclaude Registre des cancers du Tarn IUCT O - INSERM UMR1027 équipe EQUITY, Toulouse, France

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Who should attend?

Biostatisticians, statisticians, epidemiologists; researchers and students; working in a registry of cancer, of chronic disease or in any other field relevant to these methodologies and applications.

International audience.

The number of participants is limited to 40 persons.

Course language

Course will be taught in English. All instruction and course materials will be in English too.

Computing

Almost half of the course will be devoted to practical applications. Therefore, the applicants will have the opportunity to apply the methods described in the course using real or simulated data.

Computing sessions will be organised using R software. These sessions will be the opportunity for participants and for the faculty to bring them together to have exiting knowledge exchange.

Computers will be provided (Windows). Participants can use our computers or bring their own laptop computers.

Previous experience of using R software is a pre-requisite.

One week of Summer School in Corte

To acces the completes videos, the slides of videos and the practicals contents please go to this Private page

Speakers	Title
Roch Giorgi	Goals, epistemological aspects
Valérie Jooste	Indicators-Interpretation
Maja Pohar-Perme	Non-parametric estimators of net survival
Emmanuelle Dantony Zoé Uhry	Flexible parametric models for excess hazard and introduction to penalized framework. Part 1
Aurélien Belot Laurent Roche Mathieu Fauvernier	Flexible parametric models for excess hazard and introduction to penalized framework. Part 2
Bernard Rachet Edmund-Njeru Njagi	Handling missing data
Aurélien Belot Hadrien Charvat	Frailty models
Roch Giorgi	Multiple events analysis
Roch Giorgi Juste Goungounga	Handling expected rates tables (without, with missing information) and extensions to other fields: clinical research
Guy Hédelin Michel Grzebyk	Handling expected rates tables (without, with missing information) and extensions to other fields: occupational epidemiology

Scientific programme committee

Roch Giorgi (UMR 1252 SESSTIM; France); Pascale Grosclaude (FRANCIM, registre des cancers du Tarn; France); Guy Hédelin (Institut National de Recherche et de Sécurité; France); Bernard Rachet (ICON, London School of Hygiene and Tropical Medicine, Department of Non-communicable Disease Epidemiology; Angleterre); Laurent Remontet (Hospices Civiles de Lyon-UMR 5588, Université de Lyon, CNRS; France); Maja Pohar-Perme (Institute for Biostatistics and Medical Informatics; Slovenie).

Local organisers

Roch Giorgi SESSTIM, UMR 1252, ISSPAM, Inserm/IRD/Aix-Marseille Université, France

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Nathalie Grafféo SESSTIM, UMR 1252, ISSPAM, Inserm/IRD/Aix-Marseille Université, France

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Nicolas Ngo SESSTIM, UMR 1252, ISSPAM, Inserm/IRD/Aix-Marseille Université, France

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Course dinner

Thursday, July 07^th at 8:00 pm

Information concerning the location of the social dinner will be given soon.

It will be an opportunity for us to exchange in a convivial environment while tasting local products and listening to Corsican music.

Social activities

Corte tourist office

Corte city hall

Corsica tourist office

Course venue

The course will be held at the Université de Corse Pascal Paoli, at the campus Grimaldi, in Corte, Corsica, France. Theoretical parts will be in the amphitheatre Jean Nicoli, and practical parts using R software will be in computing rooms.

Getting to Corsica

General overview and transports to Corsica

Getting to Corte

By train

Main distances

Guide to Corte

Accommodation

Hotels

Course participants are responsible for booking their room directly with the hotels. After registering for the course, please book your hotel as soon as possible. Please take note of the terms and conditions of the chosen hotel (especially in case of cancellation).

Listing of hotels

Apart hotel

Accommodation

However, in order to minimize distances between the location of the course and your accommodation, we recommend to book rooms on the Grimaldi campus. The price is 36,61 euros per person per night. The sheets and towels are provided and the rooms include private bathroom and cooking facilities.

If you want to book a room there or if you need further informations, please contact Mrs. Aurélie Ciabrini by email (aurelie.ciabrini@crous-corse.fr).

About Corte

Corte tourist office

Corte city hall

Maps

Corte, course venue and hotels

Pictures

Registration includes access to the 5 days of the course, morning and afternoon tea breaks, daily lunch breaks on each day and invitation to the course reception on the evening of Thursday 07^th July.

Please note that hotel reservations must be made by participants, since the registration fees exclude travel and accommodation costs.

Course fees

Prices in EUR, incl. VAT	Early bird, until May 31st 2022	From June 01st 2022*
Participant**	650 €	750 €
ISCB Members***	550 €	650 €
Course reception****	Free	Free

*

The deadline for registration is June 15^th, 2022

**

For the Inserm members, or members of a team labelled by Inserm, training office Inserm “Provence-Alpes-Côte d’Azur et Corse” will take charge of 5 registrations of agents paid by Inserm, on the proposal of the organizer of the Corsican Summer School. Order forms, with a short summary of the interest for this advanced course, must be sent to the attention of the local organisers by email: gestion_admin.u1252@inserm.fr.

***

For the ISCB members asking for the discount, 2022 ISCB membership must be provided. See information on the online registration on how to proceed.

****

The course reception (dinner with Corsican songs) is free of charge but you must register. See below for register.

Method of payment

• Online registration
• Order form (for agents taken in charge for by Inserm).

Course reception registration

Please download the course reception registration form, fill out the form, one for each participant, and then send it by email to Mrs Daffri at: gestion_admin.u1252@inserm.fr, with the subject: “HEAR+STAT 2022”.

Cancellation reception registration

• In case of cancellation of participation until May 31^st, 2022 the registration fee will be refunded.
• After June 01^st, 2022 there will be no refund whatsoever.
• Cancellations must be communicated in written form.

Photos of one week to Corte, at the end of the course…

Lamia Daffri: gestion_admin.u1252@inserm.fr